Clinical Translation of MRgHIFU

Clinical Translation of MRgHIFU

by | Jul 23, 2024

Clinical Translation of MRgHIFU

Minimally invasive ablation of liver tumors

Project Info

Start date:
September 2024

End date:
August 2028

Funding:
Swiss National Funds (SNF)

Coordinator:
HUG – Division of Radiology

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Summary

High intensity focused ultrasound (HIFU) is a precise method to thermally ablate deep-seated tumors in a non-invasive manner. A prerequisite for a safe and effective application of HIFU is image guidance, to plan and control the ablation process. The most suitable imaging modality is MRI, with its high soft tissue contrast and its ability to monitor tissue temperature changes (MR-guided HIFU, MRgHIFU). The therapy of abdominal organs, such as the liver, still poses several problems due to a moving target location caused by breathing, motion related MR-thermometry artefacts and near-field obstacles, i.e. thoracic cage or bowel.

The primary objective of this project is to perform clinical trials with MRgHIFU applied to liver neoplastic nodules. The project relies on a new concept of MRgHIFU ultrasound developed in a previous SNF project which will be tested for the first time on patients. The clinical studies will meet incremental requirements in liver from basic targeting to complete tumour ablation.

In this project, Artanim is the expert in computer science, involving the design, implementation, and quality assurance of real time software for integration of “self-scanning” sonication with closed loop temperature feedback control.

Partners

University Hospitals of Geneva – Division of Radiology
Imaging, data analysis, transducer development, clinical tests and project coordination

University Hospitals of Geneva – Division of Oncology
Clinical trials

University Hospitals of Geneva – Department of Surgery
Liver surgery

Artanim
Design, implementation and quality assurance of real time software for integration of “self-scanning” sonification

Mocap RSA

Mocap RSA

by | Mar 27, 2021

Mocap RSA

ROM analysis of RSA

Project Info

Start date:
January 2022

End date:
June 2023

Funding:
La Tour Hospital

Coordinator:
Artanim

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Summary

The goal of this project was to motion capture and simulate reverse shoulder prostheses (RSA) to evaluate post-operative ranges of motion during daily living activities. More specifically, we were interested at better understanding resulting glenohumeral and scapulo-thoracic motions, as well as kinematic changes after RSA.

The most challenging aspect of the project was to accurately reconstruct the post-operative prostheses of the patients. Indeed, the presence of metallic implants in CT can cause substantial image artifacts, which renders the 3D reconstruction difficult to perform. To solve this issue, patients were post-operatively scanned with a dedicated imaging protocol using a cone beam CT with reduced ionization, and a registration technique was developed to register the patients’ pre-operative 3D reconstructed bony models (scapula, humerus) and the CAD models of implants on the post-operative images.

In this project, Artanim was responsible for the segmentation and reconstruction of pre-operative and post-operative 3D bony and implants models, as well as for the dynamic simulation of reverse shoulder prostheses from motion capture data. The Haute Ecole de Santé was in charge of the post-operative registration.

Partners

Artanim
Motion capture and simulation of reverse shoulder prostheses

Haute Ecole de Santé (HEdS)
3D registration of RSA models

La Tour Hospital
Clinical tests

MRgHIFU Ablation of Liver Tumors

MRgHIFU Ablation of Liver Tumors

by | Nov 21, 2020

MRgHIFU Ablation of Liver Tumors

Minimally invasive intervention

Project Info

Start date:
July 2019

End date:
June 2023

Funding:
Swiss National Funds (SNF)

Coordinator:
HUG – Division of Radiology

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Summary

High intensity focused ultrasound (HIFU) is a precise method to thermally ablate deep-seated tumors in a non-invasive manner. A prerequisite for a safe and effective application of HIFU is image guidance, to plan and control the ablation process. The most suitable imaging modality is MRI, with its high soft tissue contrast and its ability to monitor tissue temperature changes (MR-guided HIFU, MRgHIFU). The therapy of abdominal organs, such as the liver, still poses several problems due to a moving target location caused by breathing, motion related MR-thermometry artefacts and near-field obstacles, i.e. thoracic cage or bowel.

The goal of this project is to treat unresectable liver malignancies with MRgHIFU, using fast volumetric ablation. Enlarged acoustic window and enhanced focusing number of the HIFU applicator, rapid automatic control of volumetric sonication, as well as self-scanning of the lesion by exploiting the respiratory motion are envisaged in this research.

In this project, Artanim was in charge of the segmentation of target region (tumor) and organs at risk, as well as the computation of the optimal transducer positioning of the robotic assistance system taking into account the segmented structures and the coverage target area.

Partners

University Hospitals of Geneva – Division of Radiology
Imaging, data analysis, transducer development, clinical tests and project coordination

Artanim
Segmentation of target region and organs at risk, transducer positioning

University Hospitals of Geneva – Division of Oncology
Clinical tests

Related Publications

M’Rad Y, Charbonnier C, Elias de Oliveira M, Guillemin PC, Crowe LA, Kössler T, Poletti P-A, Boudabbous S, Ricoeur A, Salomir R, Lorton O. Computer-Aided Intra-Operatory Positioning of an MRgHIFU Applicator dedicated to Abdominal Thermal Therapy using Particle Swarm Optimization, IEEE Open J Eng Med Biol, IEEE, 2644-1276:1-11, 2024.
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Lorton O, Guillemin PC, M’Rad Y, Peloso A, Boudabbous S, Charbonnier C, Holman R, Crowe LA, Gui L, Poletti P-A, Ricoeur A, Terraz S, Salomir R. A Novel Concept of a Phased-Array HIFU Transducer Optimized for MR-Guided Hepatic Ablation: Embodiment and First In-Vivo Studies, Front Oncol, 30(12):899440, 2022.
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Scapulo-Thoracic Alignment in B2 Glenoids

Scapulo-Thoracic Alignment in B2 Glenoids

by | Apr 25, 2019

Scapulo-Thoracic Alignment in B2 Glenoids

Dynamic analysis

Project Info

Start date:
April 2019

End date:
December 2019

Funding:
La Tour Hospital

Coordinator:
Artanim

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Summary

Altered scapulothoracic alignment may be a contributing pathoanatomic factor to the development of the B2 pattern of osteoarthritis. The purpose of this study was to use a patient-specific 3D measurement technique coupling medical imaging and optical motion capture to evaluate and compare scapulothoracic alignment in patients with B2 glenoids. The results of this study may improve our understanding of glenohumeral pathoanatomy and posterior glenoid erosion patterns, and assist with osteoarthritis prevention.

In this project, Artanim was responsible for dynamically simulating shoulders from kinematic data.

Partners

Artanim
Modeling and simulation of the shoulder

La Tour Hospital – Division of Orthopedic and Trauma Surgery
Clinical tests

Imaging center Rive Droite SA
Radiological acquisitions 

Related Publications

Lädermann A, Athwal GS, Bothorel H, Collin P, Mazzolari A, Raiss P, Charbonnier C. Scapulothoracic Alignment Alterations in Patients with Walch Type B Osteoarthritis: An In Vivo Dynamic Analysis and Prospective Comparative Study, J Clin Med, 10(1):66, 2021.
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Reverse Shoulder Arthroplasty

Reverse Shoulder Arthroplasty

by | Dec 2, 2017

Reverse Shoulder Arthroplasty

Dynamic simulation of RSA

Project Info

Start date:
January 2017

End date:
December 2017

Funding:
Hirslanden Clinique La Colline

Coordinator:
Artanim

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Summary

The goal of this project was to simulate reverse shoulder prostheses (RSA) to evaluate the variability of several biomechanical factors and the impact on the range of motion. In particular, we were interested in evaluating the effect of glenoid lateralization, humeral inclination and critical shoulder angle (CSA). These computer-assisted simulations provided operating parameters which aimed to minimize the onset of articular conflicts and luxations.

In this project, Artanim was responsible for dynamically simulating reverse shoulder prostheses from kinematic data.

Partners

Artanim
Simulation of reverse shoulder prostheses

Hirslanden Clinique La Colline – Division of Orthopedic and Trauma Surgery
Clinical tests

Related Publications

A. Läderman, E. Tay, P. Collin, S. Piotton, J.C.H. Chiu, A. Michelet, C. Charbonnier. Effect of critical shoulder angle, glenoid lateralization and humeral inclination on range of motion in reverse shoulder arthroplasty, Bone Joint Res, 8:378-386, 2019.
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C. Charbonnier, E. Tay, P. Collin, S. Piotton, J.C.H. Chiu, A. Michelet, A. Läderman. Effect of critical shoulder angle, glenoid lateralization and humeral inclination on ROM in reverse shoulder arthroplasty, Swiss Med Wkly, 149(Suppl. 236):2S, 2019.
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