MRgHIFU Ablation of Liver Tumors

MRgHIFU Ablation of Liver Tumors

MRgHIFU Ablation of Liver Tumors

Minimally invasive intervention

Project Info

Start date:
July 2019

End date:
June 2022

Funding:
Swiss National Funds (SNF)

Coordinator:
HUG – Division of Radiology

Summary

High intensity focused ultrasound (HIFU) is a precise method to thermally ablate deep-seated tumors in a non-invasive manner. A prerequisite for a safe and effective application of HIFU is image guidance, to plan and control the ablation process. The most suitable imaging modality is MRI, with its high soft tissue contrast and its ability to monitor tissue temperature changes (MR-guided HIFU, MRgHIFU). The therapy of abdominal organs, such as the liver, still poses several problems due to a moving target location caused by breathing, motion related MR-thermometry artefacts and near-field obstacles, i.e. thoracic cage or bowel.

The goal of this project is to treat unresectable liver malignancies with MRgHIFU, using fast volumetric ablation. Enlarged acoustic window and enhanced focusing number of the HIFU applicator, rapid automatic control of volumetric sonication, as well as self-scanning of the lesion by exploiting the respiratory motion are envisaged in this research.

In this project, Artanim is in charge of the segmentation of target region (tumor) and organs at risk, as well as the computation of the optimal transducer positioning of the robotic assistance system taking into account the segmented structures and the coverage target area.

Partners

University Hospitals of Geneva – Division of Radiology
Imaging, data analysis, transducer development, clinical tests and project coordination

Artanim
Segmentation of target region and organs at risk, transducer positioning

University Hospitals of Geneva – Division of Oncology
Clinical tests

Scapulo-Thoracic Alignment in B2 Glenoids

Scapulo-Thoracic Alignment in B2 Glenoids

Scapulo-Thoracic Alignment in B2 Glenoids

Dynamic analysis

Project Info

Start date:
April 2019

End date:
December 2019

Funding:
La Tour Hospital

Coordinator:
Artanim

Summary

Altered scapulothoracic alignment may be a contributing pathoanatomic factor to the development of the B2 pattern of osteoarthritis. The purpose of this study is to use a patient-specific 3D measurement technique coupling medical imaging and optical motion capture to evaluate and compare scapulothoracic alignment in patients with B2 glenoids. The results of this study may improve our understanding of glenohumeral pathoanatomy and posterior glenoid erosion patterns, and assist with osteoarthritis prevention.

In this project, Artanim is responsible for dynamically simulating shoulders from kinematic data.

Partners

Artanim
Modeling and simulation of the shoulder

La Tour Hospital – Division of Orthopedic and Trauma Surgery
Clinical tests

Imaging center Rive Droite SA
Radiological acquisitions

 

Reverse Shoulder Arthroplasty

Reverse Shoulder Arthroplasty

Reverse Shoulder Arthroplasty

Dynamic simulation of RSA

Project Info

Start date:
January 2017

End date:
December 2017

Funding:
Hirslanden Clinique La Colline

Coordinator:
Artanim

Summary

The goal of this project is to simulate reverse shoulder prostheses (RSA) to evaluate the variability of several biomechanical factors and the impact on the range of motion. In particular, we are interested in evaluating the effect of glenoid lateralization, humeral inclination and critical shoulder angle (CSA). These computer-assisted simulations will provide operating parameters which aim to minimize the onset of articular conflicts and luxations.

In this project, Artanim is responsible for dynamically simulating reverse shoulder prostheses from kinematic data.

Partners

Artanim
Simulation of reverse shoulder prostheses

Hirslanden Clinique La Colline – Division of Orthopedic and Trauma Surgery
Clinical tests

Related Publications

A. Läderman, E. Tay, P. Collin, S. Piotton, J.C.H. Chiu, A. Michelet, C. Charbonnier. Effect of critical shoulder angle, glenoid lateralization and humeral inclination on range of motion in reverse shoulder arthroplasty, Bone Joint Res, 8:378-386, 2019.
PDF

C. Charbonnier, E. Tay, P. Collin, S. Piotton, J.C.H. Chiu, A. Michelet, A. Läderman. Effect of critical shoulder angle, glenoid lateralization and humeral inclination on ROM in reverse shoulder arthroplasty, Swiss Med Wkly, 149(Suppl. 236):2S, 2019.
PDF

 

 

ArthroPlanner

ArthroPlanner

ArthroPlanner

Surgical planning solutions

Project Info

Start date:
November 2014

End date:
October 2016

Funding:
Private

Coordinator:
Artanim

Summary

The goal of this project is to develop several surgical planning tools taking into account both the anatomy and kinematics of the patient’s joint. We intend to continue and extend our previous research works by integrating them into a 3D surgical planning solution, called ArthroPlanner, which could be used in clinical routine and could thus directly benefit patients.

This project mainly aims at developing solutions for the dynamic planning of the hip and shoulder and to extend our work to the knee.

Related Publications

Charbonnier C, Chagué S, Kevelham B, Preissmann D, Kolo FC, Rime O, Lädermann A. ArthroPlanner: A Surgical Planning Solution for Acromioplasty, Int J CARS, 13(12):2009-2019, 2018.
PDF

Charbonnier C, Chagué S, Kolo FC, Duthon VB, Menetrey J. Multi-body Optimization with Subject-Specific Knee Models: Performance at High Knee Flexion Angles, Comput Meth Biomech Biomed Eng, 20(14):1571-1579, 2017.
PDF

Lädermann A, Kolo FC, Chagué S, Charbonnier C. Is acromioplasty planification useful? A prospective randomized trial, XIVe Congrès de la Société Francophone d’Arthroscopie, Paris, France, Revue de chirurgie orthopédique et traumatologique, 103(8):S268, September 2017.
PDF

Charbonnier C, Kolo FC, Lädermann A. Acromioplasty Planification: A Randomized Prospective Study, 27th Annual Congress of the European Shoulder and Elbow Society (SECEC), Berlin, Germany, September 2017.
PDF

Charbonnier C, Chagué S, Kevelham B, Kolo FC, Lädermann A. ArthroPlanner: A Surgical Planning Solution for Acromioplasty, 30th International Congress of Computer Assisted Radiology and Surgery, Heidelberg, Germany, Int J CARS, June 2016.
PDF

Shoulder Instability

Shoulder Instability

Shoulder Instability

Dynamic evaluation of instability

Project Info

Start date:
August 2014

End date:
July 2016

Funding:
La Tour Hospital

Coordinator:
Artanim

Summary

Shoulder instability is a common pathology in young or athletic adult that results in chronic dislocations or subluxations. When multiple dislocations episodes occur, surgical treatment is indicated. But this treatment really stabilizes the joint or only prevents it to dislocate?

The objective of this study is to investigate and compare the shoulder stability in patients with anterior instability by performing a dynamic motion capture analysis before and after surgical treatment. The results of this study will provide a better understanding of this disease, and evaluate the effectiveness of the proposed surgical treatment.

Partners

Artanim
Modeling and simulation of the shoulder

La Tour Hospital – Division of Orthopedic and Trauma Surgery
Clinical tests

Imaging center Rive Droite SA
Radiological acquisitions

Related Publications

Lädermann A, Denard PJ, Tirefort J, Chagué S, Cunningham G, Charbonnier C. Est-ce que les stabilisations d’épaule stabilisent les épaules ?, Congrès de la Société Francophone d’Arthroscopie 2016, Paris, France, Revue de chirurgie orthopédique et traumatologique, 102(8):S284-S285, December 2016.
PDF

Lädermann A, Denard PJ, Tirefort J, Kolo FC, Chagué S, Cunningham G, Charbonnier C. Does Surgery for Instability of the Shoulder Truly Stabilize the Glenohumeral Joint? A Prospective Comparative Cohort Study, Medicine, 95(31):e4369, 2016.
PDF

Lädermann A, Charbonnier C. Kinematics of the Shoulder Joint, Leading Opinions, 2015.
PDF