Multiparametric Imaging of ORL Tumors

Multiparametric Imaging of ORL Tumors

by | Jul 15, 2019

Multiparametric Imaging of ORL Tumors

Contouring for radiotherapy planning

Project Info

Start date:
January 2018

End date:
December 2020

Funding:
Swiss National Funds (SNF)

Coordinator:
HUG – Division of Radiology

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Summary

This project aimed to improve the image-based diagnosis and treatment of head and neck squamous cell carcinoma. Multiparametric imaging with morphological MRI, diffusion-weighted MRI (DW-MRI), dynamic contrast enhanced MRI (DCE-MRI) and PET may offer precise tumor and lymph node staging, improved risk stratification and effective management of patients with primary and recurrent head and neck cancer. Moreover, by combining multiparametric data, target volume delineation and biological dose painting for radiotherapy planning can be improved. The goal of this project was to improve tumor diagnosis and tailor therapeutic approaches in view of a personalized treatment strategy.

In this project, Artanim was in charge of 3D tumors reconstruction and participated in the development of an histologically validated computer-aided tumor model for the accurate contouring of gross tumor volume for radiotherapy planning.

Partners

University Hospitals of Geneva – Division of Radiology
Imaging, data analysis, radiologic-pathologic correlation and project coordination

Artanim
3D reconstruction and development of a tumor model

University Hospitals of Geneva – Division of Nuclear Medicine
Segmentation of PET images and methodological support

University of Geneva – Division of Clinical Pathology
Pathological evaluation and radiologic-pathologic correlation

University Hospitals of Geneva – Clinic of Otorhinolaryngology
Surgical dissection of tumor specimen and radiologic-pathologic correlation

Scapulo-Thoracic Alignment in B2 Glenoids

Scapulo-Thoracic Alignment in B2 Glenoids

by | Apr 25, 2019

Scapulo-Thoracic Alignment in B2 Glenoids

Dynamic analysis

Project Info

Start date:
April 2019

End date:
December 2019

Funding:
La Tour Hospital

Coordinator:
Artanim

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Summary

Altered scapulothoracic alignment may be a contributing pathoanatomic factor to the development of the B2 pattern of osteoarthritis. The purpose of this study was to use a patient-specific 3D measurement technique coupling medical imaging and optical motion capture to evaluate and compare scapulothoracic alignment in patients with B2 glenoids. The results of this study may improve our understanding of glenohumeral pathoanatomy and posterior glenoid erosion patterns, and assist with osteoarthritis prevention.

In this project, Artanim was responsible for dynamically simulating shoulders from kinematic data.

Partners

Artanim
Modeling and simulation of the shoulder

La Tour Hospital – Division of Orthopedic and Trauma Surgery
Clinical tests

Imaging center Rive Droite SA
Radiological acquisitions 

Related Publications

Lädermann A, Athwal GS, Bothorel H, Collin P, Mazzolari A, Raiss P, Charbonnier C. Scapulothoracic Alignment Alterations in Patients with Walch Type B Osteoarthritis: An In Vivo Dynamic Analysis and Prospective Comparative Study, J Clin Med, 10(1):66, 2021.
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ArthroPlanner

ArthroPlanner

by | Oct 14, 2016

ArthroPlanner

Surgical planning solutions

Project Info

Start date:
November 2014

End date:
October 2016

Funding:
Private

Coordinator:
Artanim

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Summary

The goal of this project was to develop several surgical planning tools taking into account both the anatomy and kinematics of the patient’s joint. We intended to continue and extended our previous research works by integrating them into a 3D surgical planning solution, called ArthroPlanner, which could be used in clinical routine and could thus directly benefit patients.

This project mainly aimed at developing solutions for the dynamic planning of the hip and shoulder and at extending our work to the knee.

Related Publications

Lädermann A, Chagué S, Preissmann D, Kolo FC, Zbinden O, Kevelham B, Bothorel H, Charbonnier C. Acromioplasty during repair of rotator cuff tears removes only half of the impinging acromial bone, JSES Open Access, 4(3):592-600, 2020.
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Lädermann A, Chagué S, Preissmann D, Kolo FC, Rime O, Kevelham B, Bothorel H, Charbonnier C. Guided versus Freehand acromioplasty during rotator cuff repair. A randomized prospective study, Orthop Traumatol Surg Res, 106(4):651-659, 2020.
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Lädermann A, Chagué S, Preissmann D, Kolo FC, Rime O, Kevelham B, Bothorel H, Charbonnier C. L’acromioplastie guidée comparée à l’acromioplastie à main levée dans la réparation de la coiffe des rotateurs. Une étude prospective randomisée, Revue de chirurgie orthopédique et traumatologique, 106(4):372-380, 2020.
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Charbonnier C, Duthon VB, Chagué S, Kolo FC, Ménétrey J. In Vivo Static and Dynamic Lengthening Measurements of the Posterior Cruciate Ligament at High Knee Flexion Angles, Int J CARS, 15(3):555-564, 2020.
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Charbonnier C, Chagué S, Kevelham B, Preissmann D, Kolo FC, Rime O, Lädermann A. ArthroPlanner: A Surgical Planning Solution for Acromioplasty, Int J CARS, 13(12):2009-2019, 2018.
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Charbonnier C, Chagué S, Kolo FC, Duthon VB, Menetrey J. Multi-body Optimization with Subject-Specific Knee Models: Performance at High Knee Flexion Angles, Comput Meth Biomech Biomed Eng, 20(14):1571-1579, 2017.
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Lädermann A, Kolo FC, Chagué S, Charbonnier C. Is acromioplasty planification useful? A prospective randomized trial, XIVe Congrès de la Société Francophone d’Arthroscopie, Paris, France, Revue de chirurgie orthopédique et traumatologique, 103(8):S268, September 2017.
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Charbonnier C, Kolo FC, Lädermann A. Acromioplasty Planification: A Randomized Prospective Study, 27th Annual Congress of the European Shoulder and Elbow Society (SECEC), Berlin, Germany, September 2017.
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Charbonnier C, Chagué S, Kevelham B, Kolo FC, Lädermann A. ArthroPlanner: A Surgical Planning Solution for Acromioplasty, 30th International Congress of Computer Assisted Radiology and Surgery, Heidelberg, Germany, Int J CARS, June 2016.
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Shoulder Instability

Shoulder Instability

by | Jul 20, 2016

Shoulder Instability

Dynamic evaluation of instability

Project Info

Start date:
August 2014

End date:
July 2016

Funding:
La Tour Hospital

Coordinator:
Artanim

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Summary

Shoulder instability is a common pathology in young or athletic adult that results in chronic dislocations or subluxations. When multiple dislocations episodes occur, surgical treatment is indicated. But this treatment really stabilizes the joint or only prevents it to dislocate?

The objective of this study was to investigate and compare the shoulder stability in patients with anterior instability by performing a dynamic motion capture analysis before and after surgical treatment. The results of this study provided a better understanding of this disease, and evaluated the effectiveness of the proposed surgical treatment.

Partners

Artanim
Modeling and simulation of the shoulder

La Tour Hospital – Division of Orthopedic and Trauma Surgery
Clinical tests

Imaging center Rive Droite SA
Radiological acquisitions

Related Publications

Lädermann A, Denard PJ, Tirefort J, Chagué S, Cunningham G, Charbonnier C. Est-ce que les stabilisations d’épaule stabilisent les épaules ?, Congrès de la Société Francophone d’Arthroscopie 2016, Paris, France, Revue de chirurgie orthopédique et traumatologique, 102(8):S284-S285, December 2016.
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Lädermann A, Denard PJ, Tirefort J, Kolo FC, Chagué S, Cunningham G, Charbonnier C. Does Surgery for Instability of the Shoulder Truly Stabilize the Glenohumeral Joint? A Prospective Comparative Cohort Study, Medicine, 95(31):e4369, 2016.
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Lädermann A, Charbonnier C. Kinematics of the Shoulder Joint, Leading Opinions, 2015.
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Thoracic Outlet Syndrome

Thoracic Outlet Syndrome

by | Dec 15, 2014

Thoracic Outlet Syndrome

A dynamic analysis

Project Info

Start date:
March 2014

End date:
December 2014

Funding:
La Tour Hospital

Coordinator:
Artanim

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Summary

Thoracic outlet syndrome (TOS) is a rare condition that involves pain in the neck and shoulder, numbness and tingling of the fingers. It happens when the nerves or blood vessels are compressed in the thoracic outlet which is the area between the rib cage and clavicle.

The goal of this study was to better understand certain causes of TOS by performing a dynamic simulation of the shoulder complex. Repetitive arm and shoulder movements, as well as anatomical defects can play a role in the development of TOS. In this study, motion capture and medical imaging (CT, MRI) were combined to improve assessment of this condition in symptomatic patients.

Partners

Artanim
Modeling and simulation of the shoulder

La Tour Hospital – Division of Orthopedic and Trauma Surgery
Clinical tests

Imaging center Rive Droite SA
Radiological acquisitions