ORL Tumors

ORL Tumors

ORL Tumors

Multiparametric imaging

Project Info

Start date:
January 2018

End date:
December 2020

Funding:
Swiss National Funds (SNF)

Coordinator:
HUG – Division of Radiology

Summary

This project aims to improve the image-based diagnosis and treatment of head and neck squamous cell carcinoma. Multiparametric imaging with morphological MRI, diffusion-weighted MRI (DW-MRI), dynamic contrast enhanced MRI (DCE-MRI) and PET may offer precise tumor and lymph node staging, improved risk stratification and effective management of patients with primary and recurrent head and neck cancer. Moreover, by combining multiparametric data, target volume delineation and biological dose painting for radiotherapy planning can be improved. The goal of this project is to improve tumor diagnosis and tailor therapeutic approaches in view of a personalized treatment strategy.

In this project, Artanim is in charge of 3D tumors reconstruction and participates in the development of an histologically validated computer-aided tumor model for the accurate contouring of gross tumor volume for radiotherapy planning.

Partners

University Hospitals of Geneva – Division of Radiology
Imaging, data analysis, radiologic-pathologic correlation and project coordination

Artanim
3D reconstruction and development of a tumor model

University Hospitals of Geneva – Division of Nuclear Medicine
Segmentation of PET images and methodological support

University of Geneva – Division of Clinical Pathology
Pathological evaluation and radiologic-pathologic correlation

University Hospitals of Geneva – Clinic of Otorhinolaryngology
Surgical dissection of tumor specimen and radiologic-pathologic correlation

ArthroPlanner

ArthroPlanner

ArthroPlanner

Surgical planning solutions

Project Info

Start date:
November 2014

End date:
October 2016

Funding:
Private

Coordinator:
Artanim

Summary

The goal of this project is to develop several surgical planning tools taking into account both the anatomy and kinematics of the patient’s joint. We intend to continue and extend our previous research works by integrating them into a 3D surgical planning solution, called ArthroPlanner, which could be used in clinical routine and could thus directly benefit patients.

This project mainly aims at developing solutions for the dynamic planning of the hip and shoulder and to extend our work to the knee.

Related Publications

Charbonnier C, Chagué S, Kevelham B, Preissmann D, Kolo FC, Rime O, Lädermann A. ArthroPlanner: A Surgical Planning Solution for Acromioplasty, Int J CARS, In Press, 2018.
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Charbonnier C, Chagué S, Kolo FC, Duthon VB, Menetrey J. Multi-body Optimization with Subject-Specific Knee Models: Performance at High Knee Flexion Angles, Comput Meth Biomech Biomed Eng, 20(14):1571-1579, 2017.
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Lädermann A, Kolo FC, Chagué S, Charbonnier C. Is acromioplasty planification useful? A prospective randomized trial, XIVe Congrès de la Société Francophone d’Arthroscopie, Paris, France, Revue de chirurgie orthopédique et traumatologique, 103(8):S268, September 2017.
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Charbonnier C, Kolo FC, Lädermann A. Acromioplasty Planification: A Randomized Prospective Study, 27th Annual Congress of the European Shoulder and Elbow Society (SECEC), Berlin, Germany, September 2017.
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Charbonnier C, Chagué S, Kevelham B, Kolo FC, Lädermann A. ArthroPlanner: A Surgical Planning Solution for Acromioplasty, 30th International Congress of Computer Assisted Radiology and Surgery, Heidelberg, Germany, Int J CARS, June 2016.
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Shoulder Instability

Shoulder Instability

Shoulder Instability

Dynamic evaluation of instability

Project Info

Start date:
August 2014

End date:
July 2016

Funding:
La Tour Hospital

Coordinator:
Artanim

Summary

Shoulder instability is a common pathology in young or athletic adult that results in chronic dislocations or subluxations. When multiple dislocations episodes occur, surgical treatment is indicated. But this treatment really stabilizes the joint or only prevents it to dislocate?

The objective of this study is to investigate and compare the shoulder stability in patients with anterior instability by performing a dynamic motion capture analysis before and after surgical treatment. The results of this study will provide a better understanding of this disease, and evaluate the effectiveness of the proposed surgical treatment.

Partners

Artanim
Modeling and simulation of the shoulder

La Tour Hospital – Division of Orthopedic and Trauma Surgery
Clinical tests

Imaging center Rive Droite SA
Radiological acquisitions

Related Publications

Lädermann A, Denard PJ, Tirefort J, Chagué S, Cunningham G, Charbonnier C. Est-ce que les stabilisations d’épaule stabilisent les épaules ?, Congrès de la Société Francophone d’Arthroscopie 2016, Paris, France, Revue de chirurgie orthopédique et traumatologique, 102(8):S284-S285, December 2016.
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Lädermann A, Denard PJ, Tirefort J, Kolo FC, Chagué S, Cunningham G, Charbonnier C. Does Surgery for Instability of the Shoulder Truly Stabilize the Glenohumeral Joint? A Prospective Comparative Cohort Study, Medicine, 95(31):e4369, 2016.
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Lädermann A, Charbonnier C. Kinematics of the Shoulder Joint, Leading Opinions, 2015.
PDF

Thoracic Outlet Syndrome

Thoracic Outlet Syndrome

Thoracic Outlet Syndrome

A dynamic analysis

Project Info

Start date:
March 2014

End date:
December 2014

Funding:
La Tour Hospital

Coordinator:
Artanim

Summary

Thoracic outlet syndrome (TOS) is a rare condition that involves pain in the neck and shoulder, numbness and tingling of the fingers. It happens when the nerves or blood vessels are compressed in the thoracic outlet which is the area between the rib cage and clavicle.

The goal of this study is to better understand certain causes of TOS by performing a dynamic simulation of the shoulder complex. Repetitive arm and shoulder movements, as well as anatomical defects can play a role in the development of TOS. In this study, motion capture and medical imaging (CT, MRI) are combined to improve assessment of this condition in symptomatic patients.

Partners

Artanim
Modeling and simulation of the shoulder

La Tour Hospital – Division of Orthopedic and Trauma Surgery
Clinical tests

Imaging center Rive Droite SA
Radiological acquisitions

 

Shoulder3D

Shoulder3D

Shoulder3D

Shoulder kinematic modeling

Project Info

Start date:
June 2012

End date:
March 2014

Funding:
La Tour Hospital

Coordinator:
Artanim

Summary

The shoulder has the widest range of motion of any joint in the body, but at the cost of inherent instability causing pain and functional disability. To better understand the mechanisms involved in shoulder stability, an in-depth analysis of the shoulder kinematics is instrumental. Therefore, the project aims at developing a new kinematic model to reliably evaluate the three-dimensional motion of the shoulder based on motion capture. To set up and evaluate the kinematic model, a clinical study involving tennis players is performed.

The expected results could open up new possibilities to orthopedic surgeons in order to improve assessment and treatment of patients with shoulder functional abnormalities.

Partners

Artanim
Modeling and simulation of the shoulder

La Tour Hospital – Division of Orthopedic and Trauma Surgery
Clinical tests

Imaging center Rive Droite SA
Radiological acquisitions

Related Publications

Lädermann A, Bonnevialle N, Charbonnier C. The Shoulder in Tennis : The Different Types of Impingement & Instability, In Shoulder Concepts 2016 – Arthroscopy, Arthroplasty & Fractures, Edited by P. Boileau Sauramps Medical Montpellier, 2016.
PDF

Lädermann A, Chagué S, Kolo FC, Charbonnier C. Kinematics of the Shoulder Joint in Tennis Players, J Sci Med Sport, 19(1):56-63, 2016.
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Charbonnier C, Chagué S, Kolo FC, Lädermann A. Shoulder Motion During Tennis Serve: Dynamic and Radiological Evaluation Based on Motion Capture and Magnetic Resonance Imaging, Int J CARS, 10(8):1289-1297, 2015.
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Charbonnier C, Chagué S, Kolo FC, Chow JCK, Lädermann A. Évaluation personnalisée de l’épaule par modélisation de la cinétique articulaire, Revue de chirurgie orthopédique et traumatologique, 100(7):521, 2014.
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Charbonnier C, Chagué S, Kolo FC, Chow JCK, Lädermann A. A Patient-Specific Measurement Technique to Model Shoulder Joint Kinematics, Orthop Traumatol Surg Res, 100(7):715-719, 2014.
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Lädermann A, Chagué S, Kolo FC, Charbonnier C. Kinematic of the Shoulder Joints in Professional Tennis Players, Swiss Med Wkly, Suppl. 204, 144:14S, 2014.
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Charbonnier C, Chagué S, Kolo FC, Lädermann A. A Patient-Specific Measurement Technique to Model the Kinematics of the Shoulder in Tennis Players, 14th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery (CAOS), Milan, Italy, June 2014.
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Charbonnier C, Chagué S, Kolo FC, Lädermann A. Analysis of Shoulder Impingement and Stability in Tennis Players, Proceedings of the 13th International Symposium on 3D Analysis of Human Movement, Lausanne, Switzerland, July 2014.
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Lädermann A, Chagué S, Kolo FC, Charbonnier C. Kinematic Modeling of the Shoulder in Tennis Players, 24th Annual Congress of the European Shoulder and Elbow Society (SECEC), Madrid, Spain, September 2013.