MRgHIFU Ablation of Liver TumorsMinimally invasive intervention
Swiss National Funds (SNF)
HUG – Division of Radiology
High intensity focused ultrasound (HIFU) is a precise method to thermally ablate deep-seated tumors in a non-invasive manner. A prerequisite for a safe and effective application of HIFU is image guidance, to plan and control the ablation process. The most suitable imaging modality is MRI, with its high soft tissue contrast and its ability to monitor tissue temperature changes (MR-guided HIFU, MRgHIFU). The therapy of abdominal organs, such as the liver, still poses several problems due to a moving target location caused by breathing, motion related MR-thermometry artefacts and near-field obstacles, i.e. thoracic cage or bowel.
The goal of this project is to treat unresectable liver malignancies with MRgHIFU, using fast volumetric ablation. Enlarged acoustic window and enhanced focusing number of the HIFU applicator, rapid automatic control of volumetric sonication, as well as self-scanning of the lesion by exploiting the respiratory motion are envisaged in this research.
In this project, Artanim was in charge of the segmentation of target region (tumor) and organs at risk, as well as the computation of the optimal transducer positioning of the robotic assistance system taking into account the segmented structures and the coverage target area.
University Hospitals of Geneva – Division of Radiology
Imaging, data analysis, transducer development, clinical tests and project coordination
Segmentation of target region and organs at risk, transducer positioning
University Hospitals of Geneva – Division of Oncology
Lorton O, Guillemin PC, M’Rad Y, Peloso A, Boudabbous S, Charbonnier C, Holman R, Crowe LA, Gui L, Poletti P-A, Ricoeur A, Terraz S, Salomir R. A Novel Concept of a Phased-Array HIFU Transducer Optimized for MR-Guided Hepatic Ablation: Embodiment and First In-Vivo Studies, Front Oncol, 30(12):899440, 2022.